The cattle trail that led to western Kansas and was made after laws were passed against Texas cattle because of the Texas Fever.
The trail began near San Antonio and then moved up to Fort Griffin, then crossed the Red River (the present day border of Texas with Oklahoma) . It then headed north through Indian territory across several rivers (that were actually necessary for the watering of the cattle) then on to Dodge City where the trail headed north to Colby Kansas and then onto Ogallala, Nebraska. It was there that the Union Pacific Railroad had constructed cattle pens and loading chutes.
Beyond that there were several other destinations like Deadwood, and some Forts near the Canadian border.